Christianity left notable traces along the historic Silk Road, influencing cultures and communities across vast distances. Starting from the early centuries AD, the religion began its journey eastward, carried by missionaries, merchants, and travelers.

The Nestorian branch of Christianity was particularly active on the Silk Road. Nestorian missionaries, driven by a desire to spread the gospel, traversed the arduous routes. They established churches and monasteries in key cities, such as Merv in Central Asia and Chang'an in China. These religious institutions became centers of worship, education, and cultural exchange.

In these places, Christian teachings were translated into local languages, and the Bible was copied and distributed. Artistic expressions of Christianity also emerged, with churches adorned with frescoes depicting scenes from the life of Jesus. These artworks not only served a religious purpose but also introduced new aesthetic concepts to local art.

However, over time, political changes and the rise of other religions in some regions affected the prominence of Christianity on the Silk Road. Despite this, the traces of Christianity remain, seen in archaeological discoveries, historical texts, and the cultural memory of the areas it once touched.